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656 B
1
Indexable
Hyperuricemia  
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Increased serum uric acid levels (>6.8 mg/dL)  
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Supersaturation of uric acid in blood  
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Formation of monosodium urate (MSU) crystals  
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Crystal deposition in synovial joints and tissues  
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Activation of the innate immune system  
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Neutrophil recruitment and phagocytosis of crystals  
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Release of inflammatory cytokines (IL-1β, TNF-α, IL-6)  
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Intense inflammation of the joint  
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**Acute Gout Attack**  
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Repeated episodes and persistent hyperuricemia  
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Tophi formation and chronic inflammation  
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**Chronic Gout and Joint Deformity**  
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