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Hyperuricemia ↓ Increased serum uric acid levels (>6.8 mg/dL) ↓ Supersaturation of uric acid in blood ↓ Formation of monosodium urate (MSU) crystals ↓ Crystal deposition in synovial joints and tissues ↓ Activation of the innate immune system ↓ Neutrophil recruitment and phagocytosis of crystals ↓ Release of inflammatory cytokines (IL-1β, TNF-α, IL-6) ↓ Intense inflammation of the joint ↓ **Acute Gout Attack** ↓ Repeated episodes and persistent hyperuricemia ↓ Tophi formation and chronic inflammation ↓ **Chronic Gout and Joint Deformity**
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