Untitled

df = pd.read_csv("https://raw.githubusercontent.com/selva86/datasets/master/mpg_ggplot2.csv")

fig = plt.figure(figsize=(16, 10), dpi= 80)
grid = plt.GridSpec(4, 4, hspace=0.5, wspace=0.2)

ax_main = fig.add_subplot(grid[:-1, :-1])
ax_right = fig.add_subplot(grid[:-1, -1], xticklabels=[], yticklabels=[])
ax_bottom = fig.add_subplot(grid[-1, 0:-1], xticklabels=[], yticklabels=[])

ax_main.scatter('displ', 'hwy', s=df.cty*4, c=df.manufacturer.astype('category').cat.codes, alpha=.9, data=df, cmap="tab10", edgecolors='gray', linewidths=.5)

ax_bottom.hist(df.displ, 40, histtype='stepfilled', orientation='vertical', color='deeppink')
ax_bottom.invert_yaxis()

ax_right.hist(df.hwy, 40, histtype='stepfilled', orientation='horizontal', color='deeppink')

ax_main.set(title='Scatterplot with Histograms \n displ vs hwy', xlabel='displ', ylabel='hwy')
ax_main.title.set_fontsize(20)
for item in ([ax_main.xaxis.label, ax_main.yaxis.label] + ax_main.get_xticklabels() + ax_main.get_yticklabels()):
    item.set_fontsize(14)

xlabels = ax_main.get_xticks().tolist()
ax_main.set_xticklabels(xlabels)
plt.show()